The Low Molecular Weight Heparin Tinzaparin Attenuates Platelet Activation in Terms of Metastatic Niche Formation by Coagulation-Dependent and Independent Pathways

An intimate interplay with platelets is an initial key issue for tumor cells in terms of hematogenous metastasis.Tumor cells activate platelets by different pathways and receive, upon forming a platelet cloak, protection from immune surveillance and support in metastatic niche creation.Therapeutic intervention with this early interaction is promisi

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